Category: Plenary

Russ B. Altman, MD., Ph.D.

Chairman, Department of Bioengineering, Stanford University

 Dr. Altman is a professor of bioengineering, genetics, & medicine (and of computer science by courtesy) and chairman of the bioengineering department at Stanford University. His primary research interests are in the application of computing technology to basic molecular biological problems of relevance to medicine. He is currently developing techniques for collaborative scientific computation over the internet, including novel user interfaces to biological data, particularly for pharmacogenomics. Other work focuses on the analysis of functional microenvironments within macromolecules and the application of algorithms for determining the structure, dynamics and function of biological macromolecules. Dr. Altman holds an M.D. from Stanford Medical School, a Ph.D. in medical information sciences from Stanford, and an A.B. from Harvard College.

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Douglas B. Fridsma, MD., Ph.D., FACMI.

President and Chief Executive Officer of American Medical Informatics Association, Arizona State University

Doug Fridsma, MD, PhD, FACP, FACMI, is the President and Chief Executive Officer of AMIA, a $6.2 million 501 c (3) membership society representing 5000 professional and student informaticians and their interests and activities in academe, industry, government and nonprofit organizations. AMIA’s sphere of influence focuses on both research and practice within the five primary informatics domains—translational bioinformatics, clinical research, consumer, public health and clinical informatics.

Dr. Fridsma is well-known in the informatics and healthcare community as an expert in informatics, interoperability, standards, and health IT (including meaningful use). His understanding of the science and application of informatics and experience as practitioner and policymaker give him a depth of knowledge well-suited to the critical challenge of transforming health and health care.

Prior to joining AMIA, Dr. Fridsma was the Chief Science Officer for the Office of the National Coordinator for Health Information Technology, responsible for the portfolio of technical resources needed to support the meaningful use program and health information technology interoperability.  He was engaged in key initiatives involving the Federal Health Architecture; the Patient Centered Outcomes Research Trust Fund (PCOR-TF) and the Standards and Implementation Framework.

Dr. Fridsma’s professional experience also includes academic appointments at the Arizona State University/University of Arizona, Department of Biomedical Informatics; the University of Arizona Medical School; the University of Pittsburgh, Department of Medicine and Department of Biomedical Informatics; and Stanford University Medical Center (Fellow, National Library of Medicine). His clinical practice was with the Mayo Clinic, Scottsdale, Arizona. He is also a published author with 25+ refereed articles, and 80+ conference papers, posters, presentations, talks and panels.

Dr. Fridsma received a Bachelor’s in Biomedical Sciences from the University of Michigan, and a Medical Doctorate degree  in Internal Medicine from the University of Michigan School of Medicine—Inteflex. His Doctorate is in Biomedical Informatics from the Stanford University School of Medicine.

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Edward Livingston, MD.

Deputy Editor, The Journal of The American Medical Association (JAMA)

Edward H. Livingston, M.D., F.A.C.S., A.G.A.F., has served as Deputy Editor for Clinical Content of JAMA, The Journal of the American Medical Association since July 1, 2012. Before that, he was a Contributing Editor at JAMA for 3 years.

Born and raised in Los Angeles, Dr. Livingston received his Medical Degree from UCLA. He completed a General Surgery Residency at UCLA and served as the Administrative Chief Resident for Surgery in 1992. After Residency, he remained on the faculty at UCLA eventually serving as Assistant Dean of the Medical School and Surgical Service Line Director for the VA Greater Los Angeles Health Care System. He also founded the UCLA bariatric surgery program.

In 2003, he moved to Dallas to become the Professor and Chairman of GI and Endocrine Surgery at the University Of Texas Southwestern School Of Medicine. During this time period, Dr. Livingston headed the VA’s national effort in bariatric surgery quality improvement. He was appointed as a Professor of Biomedical Engineering in 2007 at the University of Texas Arlington. Dr. Livingston became Chairman of the Graduate Program in Biomedical Engineering at UTSW in 2010.

Dr. Livingston has had peer review funding and has published in excess of 150 peer reviewed papers as well as numerous other scientific writings. He has also served on numerous local and national committees and is a past president of the Association of VA Surgeons. He continues to serve as a Professor of Surgery at UTSW.

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Shankar Subramaniam, Ph.D.

UCSD

Shankar Subramaniam is a Distinguished Professor of Bioengineering, Computer Science and Engineering, Cellular and Molecular Medicine and Nano Engineering. He was recently the Chair of the Bioengineering Department at the University of California at San Diego (2008-13). He holds the inaugural Joan and Irwin Jacobs Endowed Chair in Bioengineering and Systems Biology. He was the Founding Director of the Bioinformatics Graduate Program at the University of California at San Diego. He also has adjunct Professorships at the Salk Institute for Biological Studies and the San Diego Supercomputer Center. He is also a Professor at the Center for Cardiovascular Bioinformatics and Modeling at Johns Hopkins University and was a Guest Professor at the Center for Molecular Biology and Neuroscience at the University of Oslo in Norway. Prior to moving to UC San Diego, Dr. Subramaniam was a Professor of Biophysics, Biochemistry, Molecular and Integrative Physiology, Chemical Engineering and Electrical and Computer Engineering at the University of Illinois at Urbana-Champaign (UIUC). He was the Director of the Bioinformatics and Computational Biology Program at the National Center for Supercomputing Applications and the Co-Director of the W.M. Keck Center for Comparative and Functional Genomics at UIUC. He is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and is a recipient of Smithsonian Foundation and Association of Laboratory Automation Awards and his research work is described below. In 2013 he was elected as a Fellow of AAAS. In 2002 he received the Genome Technology All Star Award. In 2008 he was awarded the Faculty Excellence in Research Award at the University of California at San Diego. In 2011 he was appointed as a Distinguished Scientist at the San Diego Supercomputer Center. In 2014 he was appointed as a Distinguished Professor. His research spans several areas of bioinformatics and systems biology.

Subramaniam has played a key role in raising national awareness for training and research in bioinformatics. He served as a member of the National Institute for Health (NIH) Director’s Advisory Committee on Bioinformatics, which resulted in the BIOMEDICAL INFORMATION SCIENCE AND TECHNOLOGY INITIATIVE (BISTI) report. The report recognized the dire need for trained professionals in Bioinformatics and recommended the launching of a strong NIH funding initiative. Dr. Subramaniam served as the Chair of a NIH BISTI Study Section. Dr. Subramaniam has also served on Bioinformatics and Biotechnology Advisory Councils for Virginia Tech, the University of Illinois at Chicago, and on the Scientific Advisory Board of several Biotech and Bioinformatics Companies. Dr. Subramaniam has served as a member of the State of Illinois Governor’s initiative in Biotechnology and an advisor and reviewer of the State of North Carolina initiative in Biotechnology. He is currently an overseas advisor for the Department of Biotechnology of the Government of India, and a member of a European Science Foundation Panel. In 2012, he was elected as the Chair of the College of Fellows of AIMBE. He serves on the External Advisory Boards for several Bio/Biomedical Engineering Departments including Johns Hopkins U., Case Western Reserve U., U. Penn, Georgia Tech, Rice U. and UT Austin.

RESEARCH INTERESTS

Research in Subramaniam laboratory spans several areas of bioinformatics, systems biology and medicine. In bioinformatics he is involved in developing novel strategies for identifying protein interaction networks, intracellular localization of proteins and identification of functional networks in cells. In systems biology he is involved in deciphering mammalian cellular networks from high throughput and phenotypic data and in developing strategies for modeling cellular signaling networks. In systems medicine, he collaborates with biomedical scientists towards understanding diseases associated with insulin resistance and inflammation. His recent work on systems medicine involves diseases of the skeletal muscle, liver and the immune system. His laboratory is interested in mapping

the circuitry of cells to mechanisms and phenotypes in physiology and pathology and to develop quantitative models of cellular pathways.

He continues to be engaged in developing state-of-the-art infrastructure for bioinformatics. The Molecule Pages Database has been recognized as the most innovative informatics resource for signaling proteins and received the ALSIP award. The integration of highly innovative and complex computer science strategies with expert-driven cu ration has led to the Molecule Pages Database that provides comprehensive information on all known functional states of signaling molecules. The LIPID MAPS database serves as the first and only integrated resource for mammalian lipids along with their complementary gene and protein data. The microarray server, widely used by the research community combines sophisticated statistical analysis methods developed in the Subramaniam laboratory with biochemical annotations and pathways to provide biological insights into consequences of transcriptional changes in mammalian cells. He was recently awarded the NIH Data Coordination Center for Metabolomics of the Common Funds Initiative. For a list of resources, see,

http://genome.ucsd.edu/

http://www.signaling-gateway.org/

http://www.lipidmaps.org

http://workbench.sdsc.edu

http://www.bioinformatics.ucsd.edu

http://www.metabolomicsworkbench.org

Subramaniam laboratory is funded by grants from NIGMS, NHLBI, NIAID and NIDDK in the National Institutes of Health and the National Science Foundation.

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